100000 - Document - Document and Entity Information
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100010 - Statement - Consolidated Balance Sheets
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100090 - Disclosure - Cybersecurity Risk Management, Strategy, and Governance
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995455 - Disclosure - Description of Business
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995475 - Disclosure - Fair Value of Assets and Liabilities
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995525 - Disclosure - Stockholders' Equity
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995535 - Disclosure - Stock-Based Compensation
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995545 - Disclosure - Common Stock Warrants
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995555 - Disclosure - Compensation
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995565 - Disclosure - Commitment and Contingencies
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995575 - Disclosure - Net Loss Per Share
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995585 - Disclosure - Income Taxes
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995595 - Disclosure - Related Parties
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995605 - Disclosure - Segment Reporting
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995615 - Disclosure - Subsequent Events
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995625 - Disclosure - Summary of Significant Accounting Policies (Policies)
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995635 - Disclosure - Summary of Significant Accounting Policies (Tables)
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995715 - Disclosure - Net Loss Per Share (Tables)
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995725 - Disclosure - Income Taxes (Tables)
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995735 - Disclosure - Segment Reporting (Tables)
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995745 - Disclosure - Description of Business - Additional Information (Details)
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995755 - Disclosure - Summary of Significant Accounting Policies - Additional Information (Details)
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995775 - Disclosure - Fair Value of Assets and Liabilities - Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Details)
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995785 - Disclosure - Property and Equipment, Net - Schedule of Property and Equipment, Net (Details)
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995845 - Disclosure - Stockholders' Equity - Additional Information (Details)
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995855 - Disclosure - Stock-Based Compensation - Additional Information (Details)
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995865 - Disclosure - Stock-Based Compensation - Summary of stock option activity under the 2018 Plan to 2021 Plan (Details)
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995875 - Disclosure - Stock-Based Compensation - Schedule of Fair Value of Stock Options, Valuation Assumptions (Details)
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995885 - Disclosure - Stock-Based Compensation - Summary of Restricted Stock Unit Activity (Details)
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995935 - Disclosure - Commitments and Contingencies - Summary of Lease Costs (Details)
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995975 - Disclosure - Income Taxes - Additional Information (Details)
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995985 - Disclosure - Income Taxes - Schedule of Loss Before Income Taxes (Details)
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995995 - Disclosure - Income Taxes - Schedule of Income Tax Provision (Details)
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996005 - Disclosure - Income Taxes - Summary of Reconciliation of Federal Statutory Income Tax Rate to Company's Effective Tax Rate (Details)
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996015 - Disclosure - Income Taxes - Summary of Deferred Tax Assets (Liabilities) (Details)
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Statement [Line Items]
Statement [Line Items]
Liabilities, Fair Value Disclosure [Abstract]
Liability
Cybersecurity Risk Board of Directors Oversight [Text Block]
Plan Name [Domain]
Plan Name
Lease liability
Deferred Tax Assets Lease Liability
Deferred tax assets lease liability.
Entity Address, Postal Zip Code
Entity Address, Postal Zip Code
Accrued research and development expenses current.
Accrued Research And Development Expenses Current
Accrued research and development expenses
Cybersecurity Risk Board Committee or Subcommittee Responsible for Oversight [Text Block]
Clinical Preclinical and Research and Development Operations [Member]
Clinical, preclinical and research and development operations.
Clinical, Preclinical, and R&D Operations
Fair Value, Recurring and Nonrecurring [Table]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Table]
Entity Incorporation, State or Country Code
Entity Incorporation, State or Country Code
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract]
Other comprehensive items:
Trd Arr Modified Date.
Trd Arr Modified Date
Modified Date
Additional leased space commencement date.
Additional Leased Space Commencement Date
Additional leased space commencement date
Unrecognized compensation expense related to restricted stock option
Share-Based Payment Arrangement, Nonvested Award, Excluding Option, Cost Not yet Recognized, Amount
Number of operating segments
Number of Operating Segments
Federal tax credits
Effective Income Tax Rate Reconciliation, Tax Credit, Percent
Effective Income Tax Rate Reconciliation, Tax Credit, Percent, Total
Federal tax credits
upfront payment.
Upfront Payment
Upfront payment
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercisable at December 31, 2024
Deferred Tax Liabilities Prepaid Expenses and Other Current Assets
Deferred tax liabilities, prepaid expenses and other current assets.
Prepaid expenses and other current assets
Vesting of restricted stock
Stock Issued During Period, Value, Restricted Stock Award, Gross
Shares, Outstanding
Ending Balance, Shares
Beginning Balance, Shares
Fair Value Hierarchy and NAV [Axis]
Fair Value Hierarchy and NAV
Two thousand twenty one employee stock purchase plan.
Two Thousand Twenty One Employee Stock Purchase Plan [Member]
2021 Employee Stock Purchase Plan
Auditor Name
Ninth amendment.
Ninth Amendment
Federal
Deferred Federal Income Tax Expense (Benefit)
Level 2
Fair Value, Inputs, Level 2 [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]
Accounting pronouncements not yet adopted.
Accounting Pronouncements Not Yet Adopted [Policy Text Block]
Accounting Pronouncements Not Yet Adopted
Stockholder.
Stockholder [Member]
Stockholder
Required amendment payment
Required amendment payment.
Area of Real Estate Property
Area of space leased
Tax Credit Carryforward, Name [Domain]
Commitments and Contingencies Disclosure [Text Block]
Commitments and Contingencies
Description of business.
Description Of Business [Line Items]
Description Of Business [Line Items]
Stock, Class of Stock [Table]
Latest Tax Year
Latest Tax Year [Member]
Number of operating lease.
Number Of Operating Lease
Number of operating lease
Potential milestone payments.
Potential Milestone Payments
Potential milestone payments
Restricted stock units vesting increments
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Rights, Percentage
Collaborative Arrangement and Arrangement Other than Collaborative [Domain]
Collaborative Arrangement and Arrangement Other than Collaborative
Related Party Transaction [Line Items]
Cybersecurity Risk Management Processes Integrated [Text Block]
Equity [Text Block]
Stockholders' Equity
Prepaid expenses and other current assets disclosure.
Prepaid Expenses and Other Current Assets Disclosure Text Block
Prepaid Expenses and Other Current Assets
Class of Warrant or Right [Axis]
Sale of Stock [Domain]
Sale of Stock
CIK
Entity Central Index Key
subsequent payments due.
Subsequent Payments Due
Subsequent payments due
Options, Cancelled/Forfeited
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Forfeitures in Period
Number of Shares, Forfeited
Auditor Opinion [Text Block]
Auditor Opinion
Increase (Decrease) in Operating Capital [Abstract]
Changes in operating assets and liabilities:
Common Stock, Shares, Issued
Common stock, shares issued
Common Stock, Shares, Issued, Total
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table]
Schedule Of Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Table]
Business Description and Basis of Presentation [Text Block]
Description of Business
Income Statement [Abstract]
Entity Address, State or Province
Entity Address, State or Province
Warrants to Purchase Common Stock
Warrants To Purchase Common Stock [Member]
Warrants To Purchase Common Stock [Member].
License agreement expiration period
License agreement expiration period.
Employee Stock Purchase Plan Issuance
Stock Issued During Period, Value, Employee Stock Purchase Plan
Loss before income taxes
Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest
Laser Systems [Member]
Laser Systems [Member]
Laser System
Class of Warrant or Right [Table]
Deferred Tax Assets Accrued Expenses and Other Current Liabilities
Deferred tax assets, accrued expenses and other current liabilities.
Accrued expenses and other current liabilities
Accounting Standards Update [Extensible Enumeration]
One-time upfront license issuance fee
One Time Upfront License Issuance Fee
One time upfront license issuance fee.
Marketable Securities
Marketable securities
Marketable Securities, Total
Retirement Plan Name [Domain]
Retirement Plan Name
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Intrinsic Value
Aggregate Intrinsic Value, Exercisable at December 31, 2024
Schedule of accrued expenses and other current liabilities.
Schedule Of Accrued Expenses And Other Current Liabilities [Table Text Block]
Summary of Accrued Expenses and Other Current Liabilities
Series B convertible preferred stock.
Series B Convertible Preferred Stock [Member]
Series B Convertible Preferred Stock
Non-cash lease expense
Non-cash Lease Expense
Non-cash lease expense.
LI-COR, Inc.
LI-COR, Inc [Member]
L I C O R Inc [Member]
Cover
Cover [Abstract]
Comprehensive Loss
Comprehensive Income, Policy [Policy Text Block]
Net loss per common share - basic
Earnings Per Share, Basic, Total
Earnings Per Share, Basic
Net loss per share attributable to common stockholders - basic
Increase in valuation allowance
Valuation Allowance, Deferred Tax Asset, Increase (Decrease), Amount
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Gain, before Tax
Unrealized Gains
Operating Expenses [Abstract]
Operating Expenses:
Finance Lease, Principal Payments
Cash paid for amounts included in the measurement of lease liability—finance leases
Document Annual Report
401(k) Plan
Four zero one K plan.
Four Zero One K Plan [Member]
Stock options to purchase common stock.
Stock Options To Purchase Common Stock [Member]
Stock Options to Purchase Common Stock
Investments, Debt and Equity Securities [Abstract]
Share-Based Payment Arrangement, Expense
Stock-based compensation expense
Share-based compensation expense
Finance Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate—finance leases
Eighth amendment.
Eighth Amendment
Deferred tax assets:
Deferred Tax Assets, Net [Abstract]
Retained Earnings (Accumulated Deficit)
Retained Earnings (Accumulated Deficit), Ending Balance
Retained Earnings (Accumulated Deficit), Beginning Balance
Accumulated deficit
Retained Earnings (Accumulated Deficit), Total
Accumulated deficit
Plan Name [Axis]
Plan Name
Segment Reporting [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Number
Options Outstanding, Ending balance
Options Outstanding, Beginning balance
Assets, Current [Abstract]
Current assets:
Common Stock, Capital Shares Reserved for Future Issuance
Number of shares reserved for issuance
At-The-Market.
At-The-Market [Member]
ATM
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Table Text Block]
Schedule of Prepaid Expenses and Other Current Assets
Net cash used in operating activities
Net Cash Provided by (Used in) Operating Activities
Asset under Construction [Member]
Assets Under Construction
Forfeited, Weighted -Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeitures, Weighted Average Grant Date Fair Value
Expenses for patent licensing fees.
Expenses for Patent Licensing Fees
Expenses for patent licensing fees
Accumulated Other Comprehensive Income (Loss), Net of Tax, Total
Accumulated Other Comprehensive Income (Loss), Net of Tax
Accumulated other comprehensive income
Tax Period [Domain]
Operating Loss Carryforwards
Operating Loss Carryforwards, Total
Accumulated net operating loss carryforwards
Medical Affairs
Medical Affairs [Member]
Medical Affairs.
Property, Plant and Equipment, Net
Property, Plant and Equipment, Net, Ending Balance
Property, Plant and Equipment, Net, Beginning Balance
Property and equipment, net
Property and equipment, net
Lessee, Operating Lease, Liability, to be Paid, Year Four
2028
Other
Other Operating Activities, Cash Flow Statement
National Institute of Health
National Institute Of Health [Member]
National Institute of Health
Net Cash Provided by (Used in) Operating Activities [Abstract]
Cash flows from operating activities:
Fair Value, Recurring [Member]
Fair Value, Recurring
Current Income Tax Expense (Benefit), Continuing Operations [Abstract]
Current:
Schedule of Fair Value, Assets and Liabilities Measured on Recurring Basis [Table Text Block]
Financial Assets and Liabilities Measured at Fair Value on Recurring Basis
Common Stock, Par or Stated Value Per Share
Common stock, par value
Cybersecurity Risk Management Positions or Committees Responsible [Text Block]
Proceeds from sale of marketable securities
Proceeds from sale of marketable securities
Proceeds from sale of marketable securities.
Convertible preferred stock(Note 7)
Temporary Equity, Carrying Amount, Attributable to Parent
Convertible preferred stock, Ending Balance
Convertible preferred stock, Beginning Balance
Comprehensive Income (Loss), Net of Tax, Attributable to Parent [Abstract]
Comprehensive loss:
Statement of Cash Flows [Abstract]
Antidilutive Securities, Name [Domain]
Antidilutive Securities, Name
Regulatory [Member]
Regulatory.
Regulatory
Class of Warrant or Right, Number of Securities Called by Warrants or Rights
Number of Warrants converted
Entity [Domain]
Entity
Other
Deferred Tax Assets, Other
Equity Components [Axis]
Equity Components
Entity Address, Address Line One
Entity Address, Address Line One
Schedule of Earnings Per Share, Basic and Diluted [Table Text Block]
Summary of Basic and Diluted Net Loss Per Share
Series A-1 convertible preferred stock.
Series A One Convertible Preferred Stock [Member]
Series A-1 Convertible Preferred Stock
Related Party Transaction [Table]
Granted
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period
Cybersecurity Risk Process for Informing Board Committee or Subcommittee Responsible for Oversight [Text Block]
Property, Plant and Equipment [Line Items]
Property Plant And Equipment [Line Items]
Deferred:
Deferred Income Tax Expense (Benefit), Continuing Operations [Abstract]
Summary of Significant Segment Expenses [Table Text Block]
Summary of significant segment expenses.
Summary of Significant Segment Expenses
Nonoperating Income (Expense)
Total other income (expense)
Total other income
Other Segment Items
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]
Summary of Dilutive Securities Excluded from Computation of Diluted Net Loss Per Share
Aggregate milestones payment
Aggregate Milestones Payment
Aggregate milestones payment
2021 Plan
Two thousand twenty one stock option and incentive plan.
Two Thousand Twenty One Stock Option And Incentive Plan [Member]
2021 Stock Option and Incentive Plan
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Risk Free Interest Rate
Risk-free interest rate
Life Technologies
Life Technologies Corporation.
Life Technologies Corporation [Member]
Series A-2 convertible preferred stock.
Series A Two Convertible Preferred Stock [Member]
Series A-2 Convertible Preferred Stock
Investments in Debt and Marketable Equity Securities (and Certain Trading Assets) Disclosure [Text Block]
Marketable Securities
Ending Balance
Beginning Balance
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Number
Entity Voluntary Filers
Amendment
Amendment Flag
Accounting Standards Update 2016-02 [Member]
ASU 2016-02
Operating Loss Carryforwards [Table]
Total Current
Current Income Tax Expense (Benefit)
Federal
Current Federal Tax Expense (Benefit)
Operating lease liabilities
Increase (Decrease) in Operating Lease Liability
Lease liabilities, net of current portion
Long-term operating lease liability
Operating Lease, Liability, Noncurrent
Federal
Domestic Tax Jurisdiction [Member]
Corporate Debt Securities [Member]
Corporate Bonds
Depreciable assets
Deferred Tax Liabilities, Property, Plant and Equipment
Net loss
Net losses
Net loss
Lessee, Lease, Description [Table]
Lessee Lease Description [Table]
Stock options exercises, Shares
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period
Options, Exercised
Options, Exercised
Operating Costs and Expenses
Total operating expenses
Options expected to vest as of December 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Number
Options, Exercisable at December 31, 2024
Operating loss carryforwards begin to expire period
Operating Loss Carryforward begin to expire period
Operating loss carryforward begin to expire period.
Research and Development Expense [Member]
Research and Development
Other
Stockholders' Equity, Other
Equity Component [Domain]
Equity Component
Statistical Measurement [Domain]
Statistical Measurement
Document Financial Statement Error Correction [Flag]
General and Administrative Expense
General and administrative
General and Administrative Expense, Total
G&A
General and administrative
Other income (expense)
Other Nonoperating Income (Expense), Total
Other Nonoperating Income (Expense)
Other expense
Deferred offering costs
Increase (Decrease) in Deferred Offering Cost
Increase (decrease) in deferred offering cost.
State
Deferred State and Local Income Tax Expense (Benefit)
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Text Block]
Furniture and Fixtures [Member]
Office Furniture
Cybersecurity Risk Management Processes Integrated [Flag]
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents [Abstract]
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest
Net loss
Net Income (Loss), Including Portion Attributable to Noncontrolling Interest, Total
Preferred stock, shares issued
Preferred Stock, Shares Issued
Cash paid for amounts included in the measurement of lease liabilities--operating leases
Operating Lease, Payments
Operating lease expense
Operating lease expense
Proceeds from Stock Options Exercised
Proceeds from exercise of stock options
Series D-1 and D-2 convertible preferred stock.
Series D One And D Two Convertible Preferred Stock [Member]
Series D-1 and D-2 Convertible Preferred Stock
Retirement Benefits [Text Block]
Compensation
Payments for development and commercial milestones.
Payments For Development And Commercial Milestones
Payments for development and commercial milestones
Payables and Accruals [Abstract]
Clinical Development Medical [Member]
Clinical development medical.
Clinical Development Medical
Employee Stock Purchase Plan Issuance, Shares
Stock Issued During Period, Shares, Employee Stock Purchase Plans
Prepaid Expense and Other Assets, Current
Prepaid expenses and other current assets
Prepaid expenses and other current assets
Weighted Average Exercise Price, Cancelled/Forfeited
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Forfeitures in Period, Weighted Average Exercise Price
Estimated Useful Life
Property Plant And Equipment Estimated Useful Live
Property plant and equipment estimated useful live.
Collaborative Arrangement and Arrangement Other than Collaborative [Axis]
Collaborative Arrangement and Arrangement Other than Collaborative
Class of Stock [Domain]
Class of Stock
Milestone payments
Milestone payments.
Milestone Payments
Stock issuance costs.
Stock Issuance Costs
Offering costs
Stock issuance cost, net
Comprehensive Income (Loss), Net of Tax, Attributable to Parent
Total comprehensive loss
Total comprehensive loss
Common Stock, Shares, Outstanding
Common Stock, Shares, Outstanding, Ending Balance
Common Stock, Shares, Outstanding, Beginning Balance
Common stock, shares outstanding
Fair Value Measurements
Fair Value Measurement, Policy [Policy Text Block]
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block]
Schedule of Income Tax Provision
Preferred stock, par value
Preferred Stock, Par or Stated Value Per Share
Capitalized research and development expenses
Deferred Tax Asset, In-Process Research and Development
Initial measurement of right-of-use assets and lease liabilities
Initial Measurement Of Right-of-use Assets And Lease Liabilities
Initial measurement of right-of-use assets and lease liabilities.
Rakuten [Member]
Rakuten.
Rakuten
Antidilutive Securities [Axis]
Antidilutive Securities
Cybersecurity Risk Process for Informing Management or Committees Responsible [Text Block]
Proceeds from Issuance or Sale of Equity, Total
Proceeds from Issuance or Sale of Equity
Aggregate offering price
10th Anniversary
Ten anniversary.
Foreign
Deferred Foreign Income Tax Expense (Benefit)
Entity Interactive Data Current
Entity Interactive Data Current
Marketable Securities [Table]
Accounting Standards Update [Domain]
Accounting Standards Update
Collaboration agreement period.
Collaboration Agreement Period
Agreement term
Office and laboratory facility.
Office And Laboratory Facility [Member]
Office and Laboratory Facility
Marketable Securities [Table Text Block]
Summary of Marketable Securities
Vested/Released, Weighted-Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Weighted Average Grant Date Fair Value
Cash, cash equivalents and restricted cash at end of period
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Ending Balance
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Beginning Balance
Cash, cash equivalents and restricted cash at end of period
Related Party Transactions Disclosure [Text Block]
Related Parties
Temporary equity, stock issued during period, shares, new issues
Temporary Equity Stock Issued During Period Shares New Issues
Issuance of convertible preferred stock, Shares
Statistical Measurement [Axis]
Statistical Measurement
Research Tax Credit Carryforward [Member]
Research and Development
Operating Lease, Cost
Operating lease costs
Follow-on-offering.
Follow On Offering [Member]
Follow-On Offering
Assets, Fair Value Disclosure
Financial assets
Assets, Fair Value Disclosure, Total
Related and Nonrelated Parties [Domain]
Lease, Cost
Total lease costs
Lessee, Operating Lease, Liability, to be Paid, Maturity [Table Text Block]
Summary of Future Minimum Commitments of Operating Lease Liabilities
Commercial Paper [Member]
Commercial Paper
Interest Income (Expense), after Provision for Loan Loss
Interest Income (Expense), after Provision for Loan Loss, Total
Interest income, including amortization and accretion income
Share-Based Compensation Arrangement by Share-Based Payment Award, Number of Shares Available for Grant
Number of shares available for future issuance
Federal Net Operating Loss Carryback Percentage Limited to Income in Any Year
Federal net operating loss carryback percentage limited to income in any year.
Federal net operating loss carryback percentage limited to taxable income in any year
Granted, Weighted-Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Grants in Period, Weighted Average Grant Date Fair Value
Share-Based Payment Arrangement, Nonvested Award, Cost Not yet Recognized, Period for Recognition
Unrecognized compensation expense weighted average period
Foreign Tax Jurisdiction [Member]
Foreign
Deferred Tax Assets, Net
Net deferred tax assets
Accrued Employee Benefits, Current
Accrued compensation
At The Market Offering [Member]
At The Market Offering [Member]
At-the-Market Offering
ATM
Research and Development
Research and Development Expense, Policy [Policy Text Block]
Statement of Income Location, Balance [Axis]
Income Statement Location
Assets
Total Assets
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Term
Expected term (years)
Tax Period [Axis]
Program Management [Member]
Program management.
Program Management
Foreign
Current Foreign Tax Expense (Benefit)
Foreign
Income (Loss) from Continuing Operations before Income Taxes, Foreign
Vested/Released
Number of awards vested
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period
Vested/Released, Restricted Stock Units
Restricted cash and deposits, net of current portion
Restricted Cash and Cash Equivalents, Noncurrent
Restricted Cash and Cash Equivalents, Noncurrent, Total
Long-term restricted cash, end of period
New Accounting Pronouncements, Policy [Policy Text Block]
Recently Adopted Accounting Pronouncements
Entity Address, City or Town
Entity Address, City or Town
AOCI Attributable to Parent [Member]
Accumulated Other Comprehensive Income (Loss) Amount
Equity [Abstract]
Other
Effective Income Tax Rate Reconciliation, Other Adjustments, Percent
Auditor Location
Assets, Fair Value Disclosure [Abstract]
Assets
Cybersecurity Risk Materially Affected or Reasonably Likely to Materially Affect Registrant [Flag]
Forfeited
Forfeited, Restricted Stock Units
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Forfeited in Period
Investor
Investor [Member]
Depreciation
Depreciation expense
Depreciation, Total
Net Income (Loss) Attributable to Parent [Abstract]
Numerator:
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Vested in Period, Fair Value
Restricted stock units vested with fair value
Deferred Charges, Policy [Policy Text Block]
Deferred Offering Costs
Schedule of Segment Reporting Information, by Segment [Table]
Maximum Reimbursement Cost.
Maximum Reimbursement Cost
Maximum reimbursement cost
Cybersecurity Risk Third Party Oversight and Identification Processes [Flag]
License agreement expiration term.
License Agreement Expiration Term
License agreement term
Share-Based Payment Arrangement [Text Block]
Stock-Based Compensation
Cybersecurity Risk Management Positions or Committees Responsible Report to Board [Flag]
State
Current State and Local Tax Expense (Benefit)
Prepaid Expense and Other Assets, Current [Abstract]
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay
Employer matching contribution, percent of employees contribution
Yankee Bonds [Member]
Yankee bonds.
Yankee Bonds
Number of licensed products
Number of licensed products for manufacturing.
Operating Lease, Weighted Average Discount Rate, Percent
Weighted-average discount rate—operating leases
Segment Reporting, CODM, Individual Title and Position or Group Name [Extensible Enumeration]
Fair Value Disclosures [Abstract]
Basis of Presentation and Principles of Consolidation
Basis Of Presentation And Principles Of Consolidation [Policy Text Block]
Basis of presentation and principles of consolidation
Clinical Development Operations [Member]
Clinical development operations.
Clinical Development Operations
2023 Follow-On Offering
Two Zero Two Three Follow-On Offering Member
Two Zero Two Three Follow-On Offering.
Entity Public Float
Stock Issued During Period, Value, New Issues
Issuance of common stock
Aggregate gross proceeds
Initial license fee related to additional licensed product.
Initial License Fee Related To Additional Licensed Product
Initial license fee for additional licensed product
Stock options exercises
Stock Issued During Period, Value, Stock Options Exercised
2021 Plan
Two Thousand and Eighteen and Two Thousand Twenty One Stock Options Plan [Member]
Two thousand and eighteen and two thousand twenty one stock options plan.
Lessee, Lease, Description [Line Items]
Lessee Lease Description [Line Items]
Liabilities, Current [Abstract]
Current liabilities:
Document Type
Document Type
Accounting Standards Update [Axis]
Accounting Standards Update
US Government Agencies Debt Securities [Member]
U.S. Government Agencies
Lab equipment.
Lab Equipment [Member]
Lab Equipment
Asset Impairment Charges, Total
Asset Impairment Charges
Impairments of asset
Title of 12(b) Security
Title of 12(b) Security
Series B Warrants.
Series B Warrants [Member]
Series B Warrants
Cash and cash equivalents
Cash and cash equivalents, end of period
Cash and Cash Equivalents, at Carrying Value
Cash and Cash Equivalents, at Carrying Value, Beginning Balance
Cash and Cash Equivalents, at Carrying Value, Total
Cash and cash equivalents, end of period
Accrued expenses and other current liabilities.
Accrued Expenses And Other Current Liabilities
Accrued expenses and other current liabilities
Accrued expenses and other current liabilities
Lessee, Operating Lease, Liability, to be Paid, Year Five
2029
Lease, Cost [Table Text Block]
Summary of Lease Costs
Cybersecurity Risk Management, Strategy, and Governance [Line Items]
Statement of Stockholders' Equity [Abstract]
Document Fiscal Period Focus
Change of control fees.
Change Of Control Fees
Change of control fees
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period, Intrinsic Value
Total intrinsic value of options exercised
Research and development expenses
Expenses related to license agreement
Research and Development Expense, Total
Research and development
Research and development expenses
Marketable Securities, Gain (Loss), Excluding Other-than-temporary Impairment Loss, Total
Marketable Security, Gain (Loss)
Accretion on marketable securities
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Gross
Options, Granted
Weighted-average grant date fair value of options granted
Asset-backed Securities And U.S. Government Agencies Securities
Asset-backed Securities And U.S. Government Agencies Securities [Member]
Asset-backed securities and u.s. Government agencies securities.
IND Filings
IND Filing
IND Filings [Member]
IND Filings [Member]
Earliest Tax Year
Earliest Tax Year [Member]
Asset Class [Domain]
Asset Class
Property, Plant and Equipment, Gross
Property, Plant and Equipment, Gross, Ending Balance
Property, Plant and Equipment, Gross, Beginning Balance
Property and equipment, gross
Property, Plant and Equipment, Gross, Total
Description of business.
Description Of Business [Table]
Description Of Business [Table]
Device [Member]
Device.
Device
Debt Securities, Available-for-Sale, Maturity, Allocated and Single Maturity Date, Fair Value, Total
Debt Securities, Available-for-Sale, Maturity, Allocated and Single Maturity Date, Fair Value
Marketable securities fair value, maturities of one to two years
Lessee, Leases [Policy Text Block]
Leases
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]
Schedule of Fair Value of Stock Options, Valuation Assumptions
Chemistry, Manufacturing and Controls
Chemistry, Manufacturing and Controls [Member]
Chemistry, manufacturing and controls.
Class of Warrant or Right, Exercise Price of Warrants or Rights
Exercise price of warrants
Financial Instruments [Domain]
Class Of Warrant Or Right [Line Items]
Sale of Stock [Axis]
Sale of Stock
Net Cash Provided by (Used in) Investing Activities [Abstract]
Cash flows from investing activities:
Schedule of Nonvested Restricted Stock Units Activity
Schedule of Nonvested Restricted Stock Units Activity [Table Text Block]
Retirement Plan Name [Axis]
Retirement Plan Name
Income Tax Disclosure [Text Block]
Income Taxes
Summary of Reconciliation of Federal Statutory Income Tax Rate to Company's Effective Tax Rate
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]
Cybersecurity Risk Management, Strategy, and Governance [Abstract]
Aggregate gross proceeds from follow-on offering
Proceeds From Issuance Of Follow-On Offering Gross
Proceeds from issuance of follow-on offering gross.
Defined Contribution Plan Disclosure [Line Items]
Defined Contribution Plan Disclosure [Line Items]
Aggregate milestone payments.
Aggregate Milestone Payments
Aggregate milestone payments
Series C-1 and C-2 convertible preferred stock.
Series C One And C Two Convertible Preferred Stock [Member]
Series C-1 and C-2 Convertible Preferred Stock
Other Accrued Liabilities, Current
Other
Increase (Decrease) in Accounts Payable
Accounts payable
Increase (Decrease) in Accounts Payable, Total
Deferred tax liabilities:
Deferred Tax Liabilities, Net [Abstract]
payment for each sublicense per licensed product
Payment For Each Sublicense Per Licensed Product
Payment for sublicense
Liabilities and Equity [Abstract]
Liabilities, Convertible Preferred Stock, and Stockholders’ Deficit
Document Period End Date
Document Period End Date
Net Cash Provided by (Used in) Financing Activities
Net cash provided by financing activities
Termination agreement.
Termination Agreement [Member]
Termination Agreement
Patent Licensing Reimbursement Fee
Patent Licensing Reimbursement Fee
Patent licensing reimbursement fees
ICFR Auditor Attestation Flag
Total
Total
Effective Income Tax Rate Reconciliation, Percent
Effective tax rate
Vesting of restricted stock, Shares
Stock Issued During Period, Shares, Restricted Stock Award, Gross
Total potential dilutive shares
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount
APIC, Share-Based Payment Arrangement, Increase for Cost Recognition
Stock-based compensation expense
APIC, Share-based Payment Arrangement, Increase for Cost Recognition, Total
Percentage of the lower of fair market value of common stock
Percentage Of The Lower Of Fair Market Value Of Common Stock
Percentage of the lower of the fair market value of common stock
Sale of Stock, Consideration Received on Transaction
Sale of common stock through agreement
Lessee, Operating Lease, Liability, to be Paid, after Year Five
Thereafter
Rule 10b5 1 Arr Modified.
Rule 10b5 1 Arr Modified [Flag]
Rule 10b5-1 Arrangement Modified
Income tax benefit (provision), net
Tax provision
Income tax provision, net
Income tax provision, net
Total Income Tax Provision
Disposal of equipment
Disposal Of Equipment
Disposal of equipment.
Loss on disposal of assets
Loss on disposal of assets
Gain (Loss) on Disposition of Property Plant Equipment, Total
Loss on disposal of property and equipment
Gain on disposal of property and equipment
Gain on disposal of property and equipment
Trading Symbol
Trading Symbol
Non Rule 10b 5 1 Arr Modified.
Non Rule 10b 5 1 Arr Modified [Flag]
Non-Rule 10b5-1 Arrangement Modified
Equity, Attributable to Parent
Ending Balance
Beginning Balance
Total Stockholders' Equity
Research collaboration fees
Research Collaboration Fees
Research collaboration fees
Total deferred tax assets
Deferred Tax Assets, Gross
Gross deferred tax assets
Long-Lived Tangible Asset [Axis]
Long-Lived Tangible Asset
Class of Warrant or Right, Outstanding
Warrants outstanding
Stock-Based Compensation
Share-Based Payment Arrangement [Policy Text Block]
Restricted Stock Units
Restricted Stock Units (RSUs) [Member]
Related Party Transactions [Abstract]
Temporary Equity, Shares Authorized
Convertible preferred stock, shares authorized
Variable Lease, Cost
Variable lease costs
Property, Plant and Equipment [Table]
Schedule Of Property Plant And Equipment [Table]
Cybersecurity Risk Management, Strategy, and Governance [Table]
Change in Accounting Principle, Accounting Standards Update, Adopted [true false]
Change in accounting principle, accounting standards update, adopted [true false]
Number of operating lease terminated.
Number of Operating Lease Terminated
Number of operating lease terminated
Cybersecurity Risk Management Expertise of Management Responsible [Text Block]
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]
Summary of Stock-Based Compensation Expense
Defined Contribution Plan, Employer Discretionary Contribution Amount
Matching contributions from employer
Security deposit held by lessor
Security Deposit
Total Deferred
Deferred Income Tax Expense (Benefit)
Debt Securities, Available-for-Sale, Accumulated Gross Unrealized Loss, before Tax
Unrealized Losses
Unrealized losses of marketable securities
Share-Based Payment Arrangement, Nonvested Award, Option, Cost Not yet Recognized, Amount
Unrecognized compensation expense related to stock options
Leases [Abstract]
Use of Estimates
Use of Estimates, Policy [Policy Text Block]
Number of marketable securities
Number of Marketable Securities
Number of marketable securities.
Cash and Cash Equivalents, Policy [Policy Text Block]
Cash Equivalents
Conversion of convertible preferred stock to common stock upon closing of IPO
Stock Issued During Period, Value, Conversion of Convertible Securities
Deferred Tax Liabilities, Leasing Arrangements
Right-of-use assets
Class of Stock [Line Items]
Expected dividend yield
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Dividend Rate
Expected dividend rate
Marketable Securities, Policy [Policy Text Block]
Marketable Securities
Security Exchange Name
Security Exchange Name
Operating Loss Carryforwards [Line Items]
Tax credit carryforwards
Deferred Tax Assets, Tax Credit Carryforwards
Deferred Tax Assets, Tax Credit Carryforwards, Total
Long-Lived Tangible Asset [Domain]
Long-Lived Tangible Asset
Class of Stock [Axis]
Class of Stock
Accrued interest related to uncertain tax positions
Unrecognized Tax Benefits, Interest on Income Taxes Accrued
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Ending Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Beginning Balance
Accumulated Depreciation, Depletion and Amortization, Property, Plant, and Equipment, Total
Less—accumulated depreciation
Legal Entity [Axis]
Legal Entity
Fair Value Disclosures [Text Block]
Fair Value of Assets and Liabilities
Lessee, Operating Lease, Liability, to be Paid, Year Three
2027
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value
Weighted-average grant date fair value of stock options granted
Research and Development Arrangement, Contract to Perform for Others, Type [Domain]
Capitalized Research and Development Expenditure
Capitalized Research And Development Expenditures [Member]
Capitalized research and development expenditures.
Maximum [Member]
Maximum
Liabilities and Equity
Total Liabilities and Stockholders' Equity
Operating Lease, Right-of-Use Asset
Operating lease right of use assets
Right of use assets - operating lease
Supplemental disclosure of cash flow information:
Supplemental Cash Flow Information [Abstract]
Retirement Benefits [Abstract]
Share-Based Compensation Arrangement by Share-Based Payment Award, Accelerated Vesting, Number
Number of stock awards
Net loss per common share - diluted
Earnings Per Share, Diluted, Total
Earnings Per Share, Diluted
Net loss per share attributable to common stockholders - diluted
Leasehold Improvements
Leasehold Improvements [Member]
Entity Ex Transition Period
Entity Ex Transition Period
Corporate bonds and U S government agencies securities.
Corporate Bonds And U S Government Agencies Securities [Member]
Corporate Bonds And U.S. Government Agencies Securities
Liabilities
Total Liabilities
Fair Value Hierarchy and NAV [Domain]
Fair Value Hierarchy and NAV
Assets, Current
Total current assets
Net Cash Provided by (Used in) Investing Activities
Net cash provided by (used in) investing activities
Stock Issued During Period, Shares, New Issues
Shares issued and sold
Issuance of common stock, Shares
Unrecognized tax benefits
Reserves related to uncertain tax positions
Unrecognized Tax Benefits
Unrecognized Tax Benefits, Ending Balance
Unrecognized Tax Benefits, Beginning Balance
Permanent items
Permanent Items
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent
Effective Income Tax Rate Reconciliation, Nondeductible Expense, Percent, Total
Decrease in valuation reserve
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Percent
Restricted stock units vesting duration
Share-Based Compensation Arrangement by Share-Based Payment Award, Award Vesting Period
Lessee, Operating Lease, Existence of Option to Extend [true false]
Lease existence of option to extend
Entity Filer Category
Entity Filer Category
Collaboration Research and Development Agreement.
Collaboration Research And Development Agreement [Member]
Collaboration Research and Development Agreement
Schedule Of Property Plant And Equipment Estimated Useful Life [Table Text Block]
Schedule of property, plant and equipment estimated useful life.
Schedule of Estimated Useful Lives of Property and Equipment
Property, Plant and Equipment [Abstract]
Common Stock Warrants [Member]
Common stock warrants.
Common Stock Warrants
Royalties on net sales
Royalties On Net Sales
Royalties on net sales
Payments to Acquire Marketable Securities
Purchases of marketable securities
Nonoperating Income (Expense) [Abstract]
Other income (expense):
Current Fiscal Year End Date
Current Fiscal Year End Date
Prepaid research and development expenses.
Prepaid Research And Development Expenses
Prepaid research and development expenses
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Fair Value Assets And Liabilities Measured On Recurring And Nonrecurring Basis [Line Items]
Property and Equipment
Property, Plant and Equipment, Policy [Policy Text Block]
Lessee, Operating Lease, Liability, Undiscounted Excess Amount
Less: interest
Temporary Equity, Par or Stated Value Per Share
Convertible preferred stock, par value
Share-Based Payment Arrangement, Noncash Expense
Stock-based compensation expense
Share-based Payment Arrangement, Noncash Expense, Total
Series D convertible preferred stock..
Series D Convertible Preferred Stock [Member]
Series D Convertible Preferred Stock
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Intrinsic Value
Aggregate Intrinsic Value, Outstanding, Ending balance
Aggregate Intrinsic Value, Outstanding, Beginning balance
Aggregate Intrinsic Value, Outstanding
Total intrinsic value of options exercised
Related and Nonrelated Parties [Axis]
Technology Equipment [Member]
IT Equipment
Dividends, Preferred Stock, Total
Dividends, Preferred Stock
Less: Accruals of dividends of preferred stock
Warrants Expiration Period
Warrants expiration period
Warrants expiration period
Entity Registrant Name
Entity Registrant Name
Exclusive license and supply agreement.
Exclusive License And Supply Agreement [Member]
2014 Exclusive Agreement
One time perpetual license agreement fee.
One Time Perpetual License Agreement fee
One time perpetual license agreement fee
Finance Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term—finance leases (years)
Number of Reportable Segments
Number of reportable segments
Schedule of Share-Based Compensation Arrangements by Share-Based Payment Award [Table]
Schedule Of Share Based Compensation Arrangements By Share Based Payment Award [Table]
Earnings Per Share [Text Block]
Net Loss Per Share
Entity Emerging Growth Company
Entity Emerging Growth Company
License issue fee.
License Issue Fee
License issue fee
Non-refundable, non-creditable fee.
Non Refundable Non Creditable Fee
Non-refundable, Non- creditable fee
Money Market Funds [Member]
Money Market Funds
Weighted Average Number of Shares Outstanding, Basic, Total
Weighted Average Number of Shares Outstanding, Basic
Weighted average common stock outstanding - basic
Weighted-average common stock outstanding - basic
Lessee, Operating Lease, Liability, to be Paid, Fiscal Year Maturity [Abstract]
Operating lease payments
Temporary Equity, Stock Issued During Period, Value, New Issues
Issuance of convertible preferred stock
Tax credit carryforwards begin to expire period
Tax credit carryforwards begin to expire period.
Common Stock, Shares Authorized
Common stock, shares authorized
Estimated Useful Life
Property, Plant and Equipment, Useful Life
Proceeds from Issuance of Common Stock
Proceeds from issuance of common stock
Proceeds from issuance of common stock from follow-on offering, net of issuance costs
Maturities of marketable securities
Proceeds from Sale and Maturity of Marketable Securities
Fair Value, Inputs, Level 1 [Member]
Level 1
Documents Incorporated by Reference [Text Block]
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Grants in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Granted
Financial Instrument [Axis]
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (years)
Net Loss per Share
Earnings Per Share, Policy [Policy Text Block]
General and Administrative Expense [Member]
General and Administrative
G&A
Series A convertible preferred stock.
Series A Convertible Preferred Stock [Member]
Series A Convertible Preferred Stock
Share-Based Payment Arrangement [Abstract]
Impairment of Long-Lived Assets
Impairment or Disposal of Long-Lived Assets, Policy [Policy Text Block]
Cybersecurity Risk Role of Management [Text Block]
Annual development fee.
Annual Development Fee
Annual development fee
Debt Securities, Available-for-Sale, Total
Debt Securities, Available-for-Sale
Fair Value
Accounting Policies [Abstract]
Share-Based Payment Arrangement, Option, Activity [Table Text Block]
Summary of Combined Stock Option Activity under 2018 Plan and 2021 Plan
Income Tax Disclosure [Abstract]
Initial license fee related to first licensed product.
Initial License Fee Related To First Licensed Product
Initial license fee for first licensed product
Equity, Attributable to Parent [Abstract]
Stockholders' Equity:
Operating lease termination date.
Operating Lease Termination Date
Operating lease termination date
Cash and Restricted Cash
Cash and Cash Equivalents, Restricted Cash and Cash Equivalents, Policy [Policy Text Block]
Statement [Table]
Statement [Table]
Segment Information
Segment Reporting, Policy [Policy Text Block]
Property, Plant and Equipment [Table Text Block]
Schedule of Property and Equipment, Net
Required amendment payment due period
Required amendment payment due period.
Financing lease costs.
Financing Lease Costs
Financing lease costs:
Increase (Decrease) in Prepaid Expenses, Other
Prepaid expenses and other assets
Preferred stock, shares authorized
Preferred Stock, Shares Authorized
Sales milestone payments.
Sales Milestone Payments
Sales milestone payments
Entity File Number
Entity File Number
Segment Reporting
Segment Reporting Disclosure [Text Block]
Asset-Backed Securities [Member]
Asset-Backed Securities
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Period Increase (Decrease), Including Exchange Rate Effect
Net decrease in cash, cash equivalents and restricted cash
Earnings Per Share [Abstract]
Stock-based compensation expense
Deferred Tax Assets, Tax Deferred Expense, Compensation and Benefits, Share-Based Compensation Cost
State taxes, net of federal benefit
Effective Income Tax Rate Reconciliation, State and Local Income Taxes, Percent
Statement of Financial Position [Abstract]
Tax Credit Carryforward [Axis]
IPO
Initial Public Offering
Total operating loss
Total operating loss
Operating Income (Loss)
Shares Issued, Price Per Share
Share price
Purchase price per share
Share-Based Compensation Arrangement by Share-Based Payment Award, Fair Value Assumptions, Expected Volatility Rate
Expected volatility of the underlying stock
Entity Shell Company
Entity Shell Company
Entity Tax Identification Number
Entity Tax Identification Number
Assets [Abstract]
Assets
Class of Warrant or Right [Domain]
Collateral deposit for corporate credit card
Cash Collateral for Borrowed Securities
Related Party Transaction, Amounts of Transaction
Related party transactions
Entity Current Reporting Status
Entity Current Reporting Status
Restricted cash and deposits
Restricted Cash and Cash Equivalents, Current
Restricted Cash and Cash Equivalents, Current, Total
Short-term restricted cash, end of period
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercisable, Weighted Average Remaining Contractual Term
Weighted Average Remaining Contractual Term (years), Exercisable
Property, Plant and Equipment Disclosure [Text Block]
Property and Equipment, Net
Subsequent Events [Abstract]
Document Fiscal Year Focus
Document Fiscal Year Focus
Change in Accounting Principle, Accounting Standards Update, Adoption Date
Change in accounting principle, accounting standards update, adoption date
payment for use of the cell line document package .
Payment For Use Of Cell Line Document Package
Payment for use of cell line document package
Purchases of property and equipment in accounts payable and accrued expenses and other liabilities
Capital Expenditures Incurred but Not yet Paid
Cash, Cash Equivalents, Restricted Cash, and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations
Cash, cash equivalents and restricted cash at end of period
Cash, cash equivalents and restricted cash at beginning of period
Cash and cash equivalents
Cash, Cash Equivalents, Restricted Cash and Restricted Cash Equivalents, Including Disposal Group and Discontinued Operations, Total
Proceeds from follow-on issuance of common stock
Proceeds from Issuance Initial Public Offering
Gross proceeds from issuance of public offering
Net proceeds from the IPO
2029 through 2037
Two Thousand Twenty Nine Through Two Thousand Thirty Seven [Member]
Two thousand twenty nine through two thousand thirty seven.
Tax Credit Carryforward
Tax Credit Carryforward, Amount
City Area Code
City Area Code
Common stock warrants disclosure.
Common Stock Warrants Disclosure [Text Block]
Common Stock Warrants
Letters of Credit Outstanding, Amount
Letters of credit
Royalty Bearing Patent License Agreement [Member]
Royalty Bearing Patent License Agreement
Royalty-bearing patent license agreement.
Liabilities, Current
Total current liabilities
Proceeds from issuance of common stock under at the market facility, net of issuance costs.
Proceeds from issuance of common stock under ATM facility, net of issuance costs
Proceeds from issuance of common stock under ATM facility, net of issuance costs
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent
Income tax provision at statutory rate
Incurred of expenses related to expansion.
Incurred Of Expenses Related To Expansion
Incurred of expenses related to expansion
Conversion of convertible preferred stock to common stock upon closing of IPO, Shares
Number of common stock upon conversion of convertible preferred stock
Stock Issued During Period, Shares, Conversion of Convertible Securities
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Local Phone Number
Local Phone Number
Preferred stock, shares outstanding
Preferred Stock, Shares Outstanding
Preferred Stock, Shares Outstanding, Ending Balance
Preferred Stock, Shares Outstanding, Beginning Balance
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded From Computation Of Earnings Per Share [Line Items]
Additional Paid in Capital
Additional Paid in Capital, Ending Balance
Additional Paid in Capital, Beginning Balance
Additional paid-in capital
Additional Paid in Capital, Total
Research and development expenditures amortization period.
Research and Development Expenditures Amortization Period
Research and development expenditures amortization period
Defined Contribution Plan, Employer Matching Contribution, Percent of Match
Matching contribution by employer, percentage
Income Tax Jurisdiction [Axis]
Income Taxes
Income Tax, Policy [Policy Text Block]
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block]
Schedule of loss before income taxes
Commitments and Contingencies Disclosure [Abstract]
Additional area of rented space.
Additional Area Of Rented Space
Additional square feet of laboratory space
Debt Securities, Available-for-Sale, Amortized Cost
Amortized Cost
Biologic materials license agreement.
Biologic Materials License Agreement [Member]
Biologic Materials License Agreement
Summary of Deferred Tax Assets (Liabilities)
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]
Less: current portion of lease liabilities
Short-term operating lease liability
Operating Lease, Liability, Current
Income Tax Jurisdiction [Domain]
Retained Earnings [Member]
Accumulated Deficit
Defined Contribution Plan [Table]
Defined Contribution Plan [Table]
Payments to Acquire Property, Plant, and Equipment
Payments to Acquire Property, Plant, and Equipment, Total
Purchases of property and equipment
Document Transition Report
Document Transition Report
Dr. John Schiller.
Dr John Schiller [Member]
Dr. John Schiller
Lessee, Operating Lease, Liability, to be Paid, Year Two
2026
Antidilutive Security, Excluded EPS Calculation [Table]
Schedule Of Antidilutive Securities Excluded From Computation Of Earnings Per Share [Table]
Proceeds from Stock Plans
Proceeds from ESPP purchases
License issue royalty fee.
License Issue Royalty Fee
License issue royalty fee
Share-Based Compensation Arrangements by Share-Based Payment Award, Options, Exercises in Period, Weighted Average Exercise Price
Weighted Average Exercise Price, Exercised
Concentration of Credit Risk
Concentration Risk, Credit Risk, Policy [Policy Text Block]
Other Segment Items
Other segment items.
Auditor Firm ID
Common Stock [Member]
Common Stock
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Employee Service Share Based Compensation Allocation Of Recognized Period Costs [Line Items]
2014 Non- Exclusive Agreement
Non-exclusive license agreement.
Non Exclusive License Agreement [Member]
Laboratory Equipment
Laboratory Equipment [Member]
Laboratory Equipment.
Unvested, Weighted -Average Grant Date Fair Value
Unvested, Weighted -Average Grant Date Fair Value
Share-Based Compensation Arrangement by Share-Based Payment Award, Equity Instruments Other than Options, Nonvested, Weighted Average Grant Date Fair Value
Increase (Decrease) in Other Noncurrent Assets
Other long-term assets
Other long-term assets
Additional Paid-in Capital [Member]
Additional Paid-in Capital
Entity Well-known Seasoned Issuer
Adjustments to Reconcile Net Income (Loss) to Cash Provided by (Used in) Operating Activities [Abstract]
Adjustments to reconcile net loss to net cash used in operating activities:
Initial license fee.
Initial License Fee
Initial license fee
Statement of Income Location, Balance [Domain]
Income Statement Location
Lessee Operating Lease Liability Payments Due Next Twelve Months, Total
Lessee, Operating Lease, Liability, to be Paid, Year One
2025
Other Assets, Noncurrent
Other long-term assets
Series E convertible preferred stock.
Series E Convertible Preferred Stock [Member]
Series E Convertible Preferred Stock
Performance-based Awards
Performance Shares [Member]
Common stock outstanding percentage.
Common Stock Outstanding Percentage
Common stock outstanding percentage
Other Assets, Current
Other
Entity Common Stock, Shares Outstanding
Entity Common Stock, Shares Outstanding
Debt Securities, Available-for-Sale, Continuous Unrealized Loss Position, Less than 12 Months
Unrealized losses of marketable securities with contractual maturities of one year or less
Basis of Presentation and Principles of Consolidation
Basis of Accounting, Policy [Policy Text Block]
Segment Reporting, Expense Information Used by CODM, Description
Other
Other Comprehensive Income Loss Other Adjustments Net Of Tax
Other comprehensive income loss other adjustments net of tax.
Preclinical [Member]
Preclinical.
Preclinical
Income (Loss) from Continuing Operations before Income Taxes, Domestic
Domestic
Common Stock, Value, Issued
Common Stock, Value, Issued, Ending Balance
Common Stock, Value, Issued, Beginning Balance
Common Stock, Value, Issued, Total
Common stock, $0.00001 par value, 150,000,000 authorized at December 31, 2024 and December 31, 2023, and 49,998,279 and 49,350,788 shares issued and outstanding at December 31, 2024 and December 31, 2023, respectively
Finance Lease, Right-of-Use Asset, Amortization
Amortization of finance right-of-use assets
Prepaid Insurance
Prepaid insurance
Gain (Loss) on Disposition of Assets
Gain (Loss) on Disposition of Assets, Total
Gain on disposal of property and equipment
Restricted Stock Units that Vest into Common Stock
Restricted Stock Units that Vest into Common Stock [Member]
Restricted stock units that vest into common stock.
Operating Lease, Liability
Operating lease liabilities
Total lease liabilities at December 31, 2024
Measurement Frequency [Axis]
Measurement Frequency
Net operating loss carryforwards
Deferred Tax Assets, Operating Loss Carryforwards
Deferred Tax Assets, Operating Loss Carryforwards, Total
Commitments and Contingencies
Commitments and Contingencies (Note 12)
New Accounting Pronouncements or Change in Accounting Principle [Line Items]
Marketable Securities [Line Items]
Marketable securities [Line items]
Quality
Quality.
Quality [Member]
Lease commencement date.
Lease Commencement Date
Lease commencement date
Weighted average common stock outstanding - diluted
Weighted Average Number of Shares Outstanding, Diluted, Total
Weighted Average Number of Shares Outstanding, Diluted
Weighted-average common stock outstanding - diluted
Significant Accounting Policies [Text Block]
Summary of Significant Accounting Policies
Research and Development Arrangement, Contract to Perform for Others, Type [Axis]
Lessee, Operating Lease, Renewal Term
Operating lease, option to extend term
Lessee, Operating Lease, Liability, to be Paid
Lessee, Operating Lease, Liability, to be Paid
Total lease payments
Estimated payments due
Cybersecurity Risk Management Third Party Engaged [Flag]
first payment due.
First Payment Due
First payment due
Weighted Average Number of Shares Outstanding, Diluted [Abstract]
Denominator:
Operating loss carryforwards subject to expiration
Operating Loss Carryforwards Subject To Expiration
Operating loss carryforwards subject to expiration.
Patent and Trademark Costs
Patent and Trademark Costs [Policy Text Block]
Patent and Trademark Costs.
Cumulative increase in shares of common stock.
Cumulative Increase In Shares Of Common Stock
Cumulative increase in shares of common stock
Entity Small Business
Entity Small Business
Segment Reporting Information [Line Items]
Cybersecurity Risk Management Processes for Assessing, Identifying, and Managing Threats [Text Block]
Accounting Standards Update and Change in Accounting Principle [Table]
New Accounting Pronouncements Or Change In Accounting Principle [Table]
Clearside
Clearside Biomedical Inc agreement.
Net Cash Provided by (Used in) Financing Activities [Abstract]
Cash flows from financing activities:
Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Outstanding, Weighted Average Exercise Price
Weighted Average Exercise Price, Ending balance
Weighted Average Exercise Price, Beginning balance
Landlord termination expense.
Landlord Termination Expense
Landlord termination expense
Net proceeds from issuance of follow on offering.
Net Proceeds From Issuance Of Follow On Offering
Net proceeds from follow-on offering
Cost and expense related to agreement including sublicense.
Cost And Expense Related To Agreement Including Sublicense
Expense related to agreement including sublicense
Asset Class [Axis]
Asset Class
Number of warrants issued.
Number of Warrants Issued
Number of warrants issued
State
State and Local Jurisdiction [Member]
Right-of-use assets obtained in exchange for operating lease liabilities
Right-of-Use Asset Obtained in Exchange for Operating Lease Liability
Measurement Frequency [Domain]
Measurement Frequency
Deferred tax assets, valuation allowance
Valuation allowance
Deferred Tax Assets, Valuation Allowance
Deferred Tax Assets, Valuation Allowance, Total
Temporary Equity, Shares Outstanding
Convertible preferred stock, Ending Balance, Shares
Convertible preferred stock, Beginning Balance, Shares
Convertible preferred stock, shares outstanding
Development and regulatory milestone payments.
Development And Regulatory Milestone Payments
Development and regulatory milestone payments
Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent
Total other comprehensive loss
Total other comprehensive loss
Total other comprehensive (loss) income
Operating Lease, Weighted Average Remaining Lease Term
Weighted-average remaining lease term—operating leases (years)
Subsequent Events [Text Block]
Subsequent Events
Gain (Loss) on Termination of Lease
Recognized loss on lease
Loss on termination of operating lease
Loss on termination of operating lease
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax, Total
OCI, Debt Securities, Available-for-Sale, Gain (Loss), after Adjustment and Tax
Unrealized loss on marketable securities
Unrealized (loss) gain on marketable securities
Unrealized gain (loss) on marketable securities
Cybersecurity Risk Management Positions or Committees Responsible [Flag]
Accounts Payable, Current
Accounts payable
Accounts Payable, Current, Total
Reimbursed expenses
Lessee, Operating Lease, Reimbursement Expense
Lessee, operating lease, reimbursement expense.
Change in Accounting Principle, Accounting Standards Update, Immaterial Effect [true false]
Change in accounting principle, accounting standards update, immaterial effect [true false]
Costs and Expenses
Expenses
Costs and Expenses, Total
Liabilities, Fair Value Disclosure
Financial liabilities
Liabilities, Fair Value Disclosure, Total
Operating loss carryforwards not subject to expiration
Operating loss carryforwards not subject to expiration.
Increase (Decrease) in Accrued Liabilities
Accrued expenses and other liabilities
Increase (Decrease) in Accrued Liabilities, Total
Short-Term Lease, Cost
Short-term lease costs
Accrued expenses and other current liabilities.
Accrued Expenses And Other Current Liabilities [Text Block]
Accrued Expenses and Other Current Liabilities